Rare genomic disorders affect less than 1/2000 people in the general population, but collectively, they are a major cause of developmental and psychiatric conditions, such as autism spectrum disorder, schizophrenia, attention deficit hyperactivity disorder, and intellectual disability. Recent advances in genomic technologies and data sharing have revolutionized the identification and diagnosis of these rare variants. Rare genomic disorders have large impacts, which allow researchers to interrogate the link between molecular function and psychiatric symptoms. However, more detailed studies are needed to fully characterize clinical presentation and risk for particular developmental and psychiatric conditions in individuals with a rare genomic variant. The G2MH consortium was initiated to address this challenge.

The G2MH consortium is structured around four projects that will study the behavioral and cognitive symptoms in individuals with rare genetic variants that confer high risk for neurodevelopmental psychiatric disorders. Participants will be identified in hospital clinics as well as in the general population across three continents.